The intestinal type is the endresult of an inflammatory process that progresses from chronic gastritis to atrophic gastritis and finally to intestinal metaplasia and dysplasia. Download as ppt, pdf, txt or read online from scribd. Niederhuber je, armitage jo, doroshow jh, kastan mb, tepper je, eds. Gastric cancer is the second leading cause of cancer related mortality and the fourth most common cancer globally. Recommendations for the diagnosis and care of gastric cancer are presented. Despite an overall decline in incidence over the last several decades, gastric cancer remains the fourth most common type of cancer and is the second leading cause of cancerrelated death worldwide. Multiple risk factors have been associated with gc in different populations. Gastric cancer is the second cause of death by cancer worldwide. Observations on the epidemiology of gastrointestinal and liver cancers in the asiapacific region.
Comprehensive molecular characterization of gastric. Asociado a gastritis cronica atrofica, metaplasia intestinal y displasia. According to the lauren classification, the disease is divided into 2 types, diffuse and intestinal, and the latter has a better prognosis. Esmo has clinical practice guidelines on the following gastrointestinal cancers. The risk that a man will develop stomach cancer in his lifetime is about 1 in 95.
This type is more common among elderly men, unlike the. Gastric cancer gc is the third leading cause of cancer death worldwide, and is divided histologically in diffuse gas tric cancer dgc and intestinal gastric cancer igc. Laurenclassification and human epidermal growth factor receptor 2 her2 status are two important pathological features of gastric cancer patients. Highrate of gc deaths reported in china, japan, and korea. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and helicobacter pylori antibody titer. Lesion precursora mas frecuente del cancer gastrico tipo intestinal. A total of 100 cases of gastric cancer were detected, 84 of which were included in the study. Among the most recognized risk factors that have been associated we can find chronic atrophic gastritis with intestinal metaplasia, helicobacter pylori infection. Cancer of the stomach and gastroesophageal junction. The american cancer society is a qualified 501c3 taxexempt organization.
But each persons risk can be affected by certain other factors1. Lauren classification combined with her2 status is a. Rectal cancer, biliary cancer, gastric cancer, oesophageal cancer, cancer of the pancreas, metastatic colorectal cancer, anal cancer, early colon cancer, familial risk colorectal cancer, hepatocellular carcinoma. The cancer genome atlas reports on molecular evaluation of 295 primary gastric adenocarcinomas and proposes a new classification of gastric cancers into 4 subtypes, which should help with clinical. Cases of gastric cancer were searched for in the database from the oncology service of our hospital, that were treated within the time frame of 2007 to 2014. In china, gastric cancer is the third most common cancer after lung cancer, liver cancer in men and lung cancer, breast cancer in women, and the third leading cause of cancerrelated death. Gastric cancer gc is highly prevalent in chile, with a mortality rate of 20100. There are, however, distinct differences in incidence rates in different geographic regions. The who world health organization classifies them as.
It has been estimated that the infection with this bacterium is responsible for 77% of the cases of distal gastric cancer and is associ ated with both types, intestinal and diffuse, but not with carcinomas originating in the gastric cardia9. In the united states, stomach malignancy is currently the 15th most common cancer. Gastric cancer is the third most common cause of cancerrelated death in the world, and it remains difficult to cure in western countries, primarily because most patients present with advanced disease. Jorge ymaya cirujano oncologo catedra oncologia, uasd. Gastric cancer treatment pdq health professional version. To reduce gastric cancer mortality, prevention is the critical approach for improvement of gastric prognosis. The level of evidence and the power of the recommendations were expressed using the grade system. Gastric cancer screening using the serum pepsinogen test method. Clinical practice guidelines on gastrointestinal cancers. Intestinal type gastric cancer has better prognosis and higher her2 positive proportion. The prognostic value of her2 in gastric cancer remains controversial. Gastric cancer is an aggressive disease that continues to have a daunting impact on global health.
In the us, the number of new cases of stomach cancer have decreased about 1. Histologic classification may predict tumor biology, clinical behavior, and outcome. Gastric cancer gc is the most common cancer with high mortality worldwide. Gastric cancer consists of two pathological variants, intestinal and diffuse. While the incidence rate of gastric cancer has been falling, that of gastric cardia cancers is reportedly on the rise in some regions.
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